Bayesian inverse problems and epidemic-threshold uncertainty for a heterogeneous SIS reaction-diffusion model

Practical Tips

Practical tips and how-to guidance will be added by our editorial team.

中文解读

中文解读待补充：本站将优先为睡眠改善、失眠治疗、助眠方法等高价值文章补充中文说明。

Article Summary

We study Bayesian inference of persistence from early observations of a heterogeneous susceptible--infected--susceptible (SIS) reaction--diffusion model with standard incidence. We show that the leading prevalence dynamics depend on the unknown coefficients only through the difference between the transmission and recovery rates and the infected diffusivity. The same pair determines the principal eigenvalue whose sign governs persistence, so early prevalence can inform the threshold even when the individual rates remain uncertain. We prove global weak well-posedness and quantitative parameter stability for the SIS system and use the resulting observation-map estimates to establish Bayesian well-posedness. For an initial infection of size $\varepsilon$, we derive a uniform second-order expansion that describes how the separate rates enter prevalence. Incidence depends explicitly on transmission at leading order. When the noise standard deviation is proportional to $\varepsilon$, we prove $O(\varepsilon)$ convergence in Hellinger distance of the nonlinear posteriors to their low-prevalence limits for both prevalence alone and joint prevalence and incidence data. We bound the principal eigenvalue using the growth rate of the infected $L^2$ norm between two times. This rate gives a lower bound for the full nonlinear system, and the upper bound separates spatial transients from nonlinear saturation. Uniform spectral estimates and bounds on infection size and measurement error give sufficient conditions for persistence and extinction. We also bound the error in posterior persistence probabilities under forward and eigenvalue approximation, accounting for posterior mass near the threshold. Numerical examples illustrate threshold inference and the predicted \(O(\varepsilon)\) convergence of the nonlinear posteriors to their low-prevalence limits in Hellinger distance.

Sources & References

• Original source
• Full article (PDF)

Comments